BDBM50251276 BN 52021::CHEMBL514432::GINKOLIDE B::Gingkolide B::ginkgolide B

SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O

InChI Key InChIKey=SQOJOAFXDQDRGF-UHFFFAOYSA-N

Data  1 KI  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50251276   

TargetPlatelet-activating factor receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 128nMAssay Description:Compound was evaluated for anti-platelet activating factor potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
Paris Diderot University

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataEC50:  180nMAssay Description:Inhibition of [3H]PAF binding to rabbit platelet membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
Paris Diderot University

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 740nMAssay Description:Inhibition of PAF-induced rabbit platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 1.70E+3nMAssay Description:Activity at human alpha-1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 3.70E+3nMAssay Description:Activity at human alpha-2GlyR expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 2.10E+3nMAssay Description:Activity at human alpha-1-beta-GlyR expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 2.90E+3nMAssay Description:Activity at human alpha-1GlyR expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
Paris Diderot University

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 418nMAssay Description:In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetPlatelet-activating factor receptor(Guinea pig)
Paris Diderot University

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 418nMAssay Description:In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetBeta-glucuronidase(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataIC50: 6.63E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
Paris Diderot University

Curated by ChEMBL
LigandPNGBDBM50251276(CHEMBL514432 | BN 52021 | ginkgolide B | Gingkolid...)
Affinity DataKi:  880nMAssay Description:Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed