BDBM50187668 3-Hydroxyflavone::3-Hydroxyflavone (12)::3-hydroxy-2-phenyl-4H-1-benzopyran-4-one::3-hydroxy-2-phenyl-4H-chromen-4-one::3-hydroxy-2-phenylchromone::CHEMBL294009::Flavonol::flavon-3-ol

SMILES Oc1c(oc2ccccc2c1=O)-c1ccccc1

InChI Key InChIKey=HVQAJTFOCKOKIN-UHFFFAOYSA-N

Data  9 KI  12 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50187668   

TargetDipeptidyl peptidase 3(Human)
Josip Juraj Strossmayer University of Osijek

LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 1.88E+5nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of flavonoids toward human DPP III was assayed in a 50 mM Tris-HCl buffer, pH 7.4. In brief, recombinant human DPP III (0.29 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2017
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of PKM2 (unknown origin) Gly128, Hie78, Hie84, Lys207, Asp177, Lys367, Ile51 residuesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 2.09E+6nMAssay Description:In vitro antibacterial activity was determined as inhibitory concentration causing 50% DNA-gyrase supercoiling inhibition (SCI)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetXanthine dehydrogenase/oxidase(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Chosun University

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to ABCB1 nucleotide binding domain 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of FASMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetCalmodulin-1(Human)
Universidad Aut£Noma Del Estado De Morelos

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 5.52E+4nMAssay Description:Inhibition of human recombinant calmodulin assessed as inhibition of calmodulin-sensitive cAMP phosphodiesterase activation after 15 mins by spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Meijo University

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 2.35E+4nMAssay Description:Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Konkuk University

LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataIC50: 4.29E+3nMAssay Description:The kinase assay was performed using the EMD Millipore KinaseProfiler service assay protocol. Aurora B kinase was supplied by EMD Millipore Corp. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetPyruvate kinase PKM(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  3.53E+3nMAssay Description:Binding affinity to PKM2 (unknown origin) assessed as oxidation of beta-NADH by spectrophotometry based LDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  5.21E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  5.54E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  5.63E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  6.59E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  6.65E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-hydroxy-2-phenyl-4H-chromen-4-one | 3-Hydroxyfla...)
Affinity DataKi:  9.30E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed