BDBM50344054 3',5-dihydroxy-4',6,7-trimethoxy flavone::6-methoxyluteolin-4',7-dimethyl ether::CHEMBL487402::eupatorin

SMILES COc1ccc(cc1O)-c1cc(=O)c2c(O)c(OC)c(OC)cc2o1

InChI Key InChIKey=KLAOKWJLUQKWIF-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50344054   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The Chinese University of Hong Kong (Shenzhen)

Curated by ChEMBL
LigandPNGBDBM50344054(3',5-dihydroxy-4',6,7-trimethoxy flavone | 6-metho...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM50344054(3',5-dihydroxy-4',6,7-trimethoxy flavone | 6-metho...)
Affinity DataKi:  35nMAssay Description:Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM50344054(3',5-dihydroxy-4',6,7-trimethoxy flavone | 6-metho...)
Affinity DataKi:  35nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
University of Crete

Curated by ChEMBL
LigandPNGBDBM50344054(3',5-dihydroxy-4',6,7-trimethoxy flavone | 6-metho...)
Affinity DataKi:  210nMAssay Description:Inhibition of CYP1A1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed