BDBM50029763 5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2,4-diamine::CHEMBL280378::Epiroprim::TCMDC-137295

SMILES CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-n1cccc1

InChI Key InChIKey=NMARPFMJVCXSAV-UHFFFAOYSA-N

Data  6 KI  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50029763   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Dihydrofolate Reductase of Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 160nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 3.00E+3nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range: 2600-3000More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 900nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined (reported by Hoffman-LaRoche group)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 6.00E+5nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by Hoffman-LaRoche group)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 4.10nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 200nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 2.60E+3nMAssay Description:In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 3.32E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii was evaluated using 90 uM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 3.32E+4nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 uM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 470nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 uM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat liver Dihydrofolate ReductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 480nMAssay Description:Inhibition of Dihydrofolate Reductase of Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 3.32E+4nMAssay Description:Inhibition of Dihydrofolate Reductase of Rat Liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 470nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase (in 90 uM dihydrofolic acid)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase from pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 480nMAssay Description:Inhibitory activity against dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Toxoplasma gondii Dihydrofolate ReductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 42nMAssay Description:Inhibition of Pneumocystis carinii Dihydrofolate ReductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii at 37 centigrade.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity was reported with purified recombinant Pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataKi:  17.4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataKi:  47nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataKi:  58.9nMAssay Description:Inhibition of human dihydrofolate reductase (DHFR) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase(Chicken)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataKi:  4.68E+4nMAssay Description:Inhibitory activity against chicken liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed