BDBM21123 (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamide::Enkephalin Amide::YDAGF-NH2

SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(N)=O

InChI Key InChIKey=RJEUERNNQHNSKG-UHFFFAOYSA-N

Data  14 KI  9 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 21123   

TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataEC50:  10.5nMAssay Description:Agonist activity at rat mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of The Punjab

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 224nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in mouse HN9.10 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of The Punjab

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 724nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 5.80nMAssay Description:Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataEC50:  154nMAssay Description:Agonist activity at MOR in Wistar rat brain membranes after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 47nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 120nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 47nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 5.80nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 120nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of The Punjab

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of The Punjab

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataIC50: 724nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataEC50:  10.5nMAssay Description:Agonist activity at rat mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in Wistar rat brain membrane after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  2.80nM ΔG°:  -11.7kcal/mole EC50:  13nMpH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2008
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Biological Research Centre of The Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  107nMAssay Description:Displacement of [3H]Ile5,6-deltorphin-2 from DOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Biological Research Centre of The Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  173nMAssay Description:Displacement of [3H]HS-665 from KOR in guinea pig brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of The Punjab

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  300nM ΔG°:  -8.89kcal/mole EC50:  190nMpH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2008
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of The Punjab

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of The Punjab

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells assessed as inhibition constant by radioligand binding as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Biological Research Centre of The Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi:  3.80E+3nMAssay Description:Displacement of [3H]DPDPE from delta-opioid receptor in Wistar rat brain membrane after 3 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details Article
PubMed
TargetCannabinoid receptor 1/2(Rat)
Biological Research Centre of The Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]JWH-018 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1/2(Rat)
Biological Research Centre of The Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21123(Enkephalin Amide | (2S)-2-{2-[(2R)-2-[(2S)-2-amino...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]WIN-55,212-2 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed