BDBM50435003 ENDOXIFEN

SMILES CC/C(=C(\c1ccc(cc1)O)/c2ccc(cc2)OCCNC)/c3ccccc3

InChI Key InChIKey=MHJBZVSGOZTKRH-UHFFFAOYSA-N

Data  5 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50435003   

TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50435003(ENDOXIFEN)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50435003(ENDOXIFEN)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human recombinant placental aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50435003(ENDOXIFEN)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of recombinant human aromatase preincubated for 10 mins followed by substrate and beta-NADP+ addition and measured for 60 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50435003(ENDOXIFEN)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human aromatase assessed as reduction in fluorescence intensity preincubated with NADPH regenerating system for 10 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50435003(ENDOXIFEN)
Affinity DataIC50: 30nMAssay Description:Binding affinity to human ERalpha measured after 2 hrs by fluorescence polarization plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed