BDBM50004233 5,11-dimethyl-2H-pyrido[4,3-b]carbazole::CHEMBL123::ELLIPTECINE::Ellipticin::Ellipticine::TCMDC-125546::cid_3213

SMILES Cc1c2[nH]c3ccccc3c2c(C)c2cnccc12

InChI Key InChIKey=CTSPAMFJBXKSOY-UHFFFAOYSA-N

Data  13 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50004233   

TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataEC50:  3.99E+3nMAssay Description:Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Missouri

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 1.82E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Missouri

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 6.08E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 19nMAssay Description:Bioactivation in CYP1A1 (unknown origin) transfected CHO cells assessed as CYP1A1-mediated drug activation by measuring reduction in cell viabilityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of topoisomerase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of p56lck autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Cnrs Umr-8113

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against c-Kit D816V type expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Cnrs Umr-8113

Curated by ChEMBL
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against c-Kit wild type expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 4.09E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay
TargetG protein-activated inward rectifier potassium channel 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataEC50:  1.49nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetStreptokinase A(Streptococcus pyogenes M1 GAS)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataEC50:  1.50E+5nMAssay Description:Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2011
Entry Details
PCBioAssay
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 3.67E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 1.67E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 6.68E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetGalanin receptor type 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataEC50: >5.57E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Florida Research Institute (TSRI) Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2011
Entry Details
PCBioAssay
TargetGalanin receptor type 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataEC50: >5.57E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Florida Research Institute, TSRI Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2011
Entry Details
PCBioAssay
TargetDiphosphomevalonate decarboxylase(Streptococcus pneumoniae D39)
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50004233(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | TCMDC-12...)
Affinity DataIC50: 1.19E+5nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay