BDBM50010702 CHEMBL411557::DYNORPHIN(1-17)-OH::Dynorphin A (1-17)::H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH::Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln::dynorphin A

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

InChI Key InChIKey=JMNJYGMAUMANNW-UHFFFAOYSA-N

Data  16 KI  10 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50010702   

TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity against Opioid receptor delta 1 in guinea pig brain homogenate using [3H]- DPDPE as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 23nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 2.5nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataEC50:  6.30nMAssay Description:Antagonist activity at human recombinant kappa opioid receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of dynorphin A-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human kappa opioid receptor transfected in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataEC50:  0.410nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by luminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 39.7nMAssay Description:Inhibition of delta-selective antagonist binding to opioid receptor of mouse vas dferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]PL-17 binding to mu opioid receptor of guinea pig brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mu-selective antagonist binding to opioid receptor of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of [3H]DPDPE binding to delta opioid receptor of guinea pig brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 0.231nMAssay Description:Inhibition of [3H]U-69593 binding to kappa opioid receptor of guinea pig brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 0.231nMAssay Description:Binding affinity against Opioid receptor kappa 1 in guinea pig brain homogenate using [3H]- U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 5nMAssay Description:Binding affinity against Opioid receptor mu 1 in guinea pig brain homogenate using [3H]- PL-17 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  3.32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  5.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
Mcgill University

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
In Depth
Date in BDB:
2/18/2013
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  7.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  8.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  12.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  42.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetNociceptin receptor(Mouse)
Mcgill University

Curated by PDSP Ki Database
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  72.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2013
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed