BDBM50047247 1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,6-dione::1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,6-dione (Denbufyllene)::1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,6-dione(denbufylline)::CHEMBL277465::Denbufylline

SMILES CCCCn1c2ncn(CC(C)=O)c2c(=O)n(CCCC)c1=O

InChI Key InChIKey=HJPRDDKCXVCFOH-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50047247   

LigandPNGBDBM50047247(1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,...)
Affinity DataIC50: 170nMAssay Description:Inhibition of phosphodiesterase 4 (PDE4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50047247(1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,...)
Affinity DataIC50: 0.170nMAssay Description:Concentration at which 50% of the activity of the Phosphodiesterase 4 from Human U937 cells is inhibitedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAdenosine receptor A1(Guinea pig)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50047247(1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,...)
Affinity DataKi:  1.65E+4nMAssay Description:Binding affinity against Adenosine A1 receptor of cerebral cortex using [3H]-CPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50047247(1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,...)
Affinity DataKi:  3.15E+4nMAssay Description:Binding affinity against Adenosine A2 receptor of striatal membrane using [3H]CGS-21680More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50047247(1,3-Dibutyl-7-(2-oxo-propyl)-3,7-dihydro-purine-2,...)
Affinity DataKi:  4.49E+4nMAssay Description:Inhibition of cAMP-phosphodiesterase (PDE) from trachealis muscle homogenate supernatantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed