BDBM50155426 1,3,5,8-Tetrahydroxy-xanthen-9-one::1,3,5,8-tetrahydroxy-9H-xanthen-9-one::CHEMBL184574::DEMETHYLBELLIDIFOLIN::Xanthen-9-one, 1.0

SMILES c1cc(c2c(c1O)C(=O)c3c(cc(cc3O2)O)O)O

InChI Key InChIKey=MPXAWSABMVLIBU-UHFFFAOYSA-N

Data  2 KI  17 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50155426   

TargetDual specificity protein kinase CLK3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 7.53E+3nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataKd:  30nMAssay Description:Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataKd:  60nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 268nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 266nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 146nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 239nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMaltase-glucoamylase(Human)
Polytechnic Institute of Braganca

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using PNPG as substrate preincubated for 15 mins followed by substrate addition by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMaltase-glucoamylase(Human)
Polytechnic Institute of Braganca

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using PNPG as substrate preincubated for 15 mins followed by substrate addition and measured after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5/P25 using full length tau as substrate by colorimetric ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Unne

Curated by ChEMBL
LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Concentration required to inhibit monoamine oxidase activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataKi:  140nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataKi:  200nM IC50: 200nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2011
Entry Details Article
PubMed