BDBM50060582 1,10-Bis(trimethyl ammonium)decane dibromide::1,10-bis-(trimethyl ammonium) decane dibromide::CHEMBL1134::DECAMETHONIUM::DECAMETHONIUM BROMIDE::Decamethonium Iodide::N,N,N'',N''-Tetramethyl-decane-1,10-diammonium; dibromide::N,N,N,N'',N'',N''-Hexamethyldecane-1,10-diammoniumdibromide::Syncurine::decane-1,10-bis(trimethylammonium bromide)

SMILES C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C

InChI Key InChIKey=MTCUAOILFDZKCO-UHFFFAOYSA-N

Data  15 KI  5 IC50  2 ITC

PDB links: 6 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50060582   

TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataIC50: 820nMAssay Description:Inhibition of histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Marbled electric ray)
UniversitÉ

LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataIC50: 1.06E+3nMpH: 4.0 T: 2°CAssay Description:The inhibitory activity of the equilibrated mixtures was determined. The activity of AChE was monitored by following the linear change in absorbance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of acetylcholine esterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhospholipase B(Cryptococcus neoformans)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Cryptococcus neoformans H99 PLB1activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  460nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
Mayo Clinic

LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  460nM ΔG°:  -8.64kcal/molepH: 7.0 T: 2°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  962nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  1.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetNicotinic acetylcholine receptor(Cape York rat)
R. J. Reynolds Tobacco

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  3.13E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
Mayo Clinic

LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity to mouse AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  5.73E+3nMAssay Description:Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetUncharacterized protein(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
TargetCholinergic receptor nicotinic alpha 6 subunit(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chicken)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat br...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
Affinity DataKi:  6.00E+6nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)

Activity Spreadsheet -- ITC Data from BindingDB

Found 2 hits for monomerid = 50060582   

HostPNGBDBM4((1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23...)
Lund University

GuestPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
ITC DataΔG°: -4.06kcal/mole −TΔS°: 1.84kcal/mole ΔH°: -5.97kcal/mole logk: 764
T: 35.05°C 
HostPNGBDBM11(betadex | beta-cyclodextrin)
Lund University

GuestPNGBDBM50060582(Decamethonium Iodide | decane-1,10-bis(trimethylam...)
ITC DataΔG°: -3.01kcal/mole −TΔS°: -1.88kcal/mole ΔH°: -1.12kcal/mole logk: 137
T: 35.05°C