BDBM50164644 2',3'-Dideoxyadenosine Triphosphate (Ddatp)::2',3'-dideoxyadenosine triphosphate::ATP,2',3'-dideoxy::CHEMBL1383::[[[5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid::ddA-TP::ddATP

SMILES c1nc(c2c(n1)n(cn2)[C@H]3CC[C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)N

InChI Key InChIKey=OAKPWEUQDVLTCN-UHFFFAOYSA-N

Data  8 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50164644   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKd:  5.30E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  20nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  50nMAssay Description:Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  75.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Pittsburgh School of Medicine

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  90nMAssay Description:Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  406nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptase (RT M184V)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  510nMAssay Description:Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | CHEM...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptase (RT M184I)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed