BDBM50370573 COTININE::US10667515, Compound (S)-cotinine::US8609708, 91 Cotinine

SMILES CN1[C@@H](CCC1=O)c2cccnc2

InChI Key InChIKey=UIKROCXWUNQSPJ-UHFFFAOYSA-N

Data  1 KI  4 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50370573   

TargetCytochrome P450 2A6(Human)
Human Biomolecular Research Institute

US Patent
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataIC50: 4.00E+5nMAssay Description:The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
Go to US Patent

TargetCytochrome P450 2A6(Human)
Human Biomolecular Research Institute

US Patent
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataIC50: 3.50E+7nMAssay Description:Inhibitory concentration against human cytochrome P450 2A6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2A5(Mouse)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataIC50: 1.50E+6nMAssay Description:Inhibitory concentration against mouse cytochrome P450 2A5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Kuopio

Curated by ChEMBL
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataIC50: 5.40E+6nMAssay Description:Inhibitory concentration against recombinant human cytochrome P450 1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetResistance to inhibitors of cholinesterase protein 3(Pig roundworm)
Iowa State University Research Foundation

US Patent
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataEC50: <1.00E+5nMAssay Description:Nematode eggs are isolated from fresh feces by centrifugation and flotation. The eggs are washed and inspected to confirm embryonation has not starte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at alpha4beta2 nAChR in rat frontal cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50370573(US8609708, 91 Cotinine | COTININE | US10667515, Co...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat frontal cortex membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed