BDBM50367032 COFORMYCIN

SMILES c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=CNC[C@H]2O

InChI Key InChIKey=YOOVTUPUBVHMPG-UHFFFAOYSA-N

Data  11 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50367032   

TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAdenosine deaminase(Bovine)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity towards calf spleen adenosine deaminase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to ADA (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAdenosine deaminase(malaria parasite P. falciparum)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as equilibrium dissocia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.110nMAssay Description:Inhibition of human erythrocytes ADA assessed as equilibrium dissociation constant by measuring reduction in formation of inosine using adenosine as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAdenosine deaminase(malaria parasite P. falciparum)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.25nMAssay Description:Inhibition of Plasmodium falciparum ADA assessed as reduction in formation of ammonia using adenosine as substrate incubated for 15 mins by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAdenosine deaminase(malaria parasite P. falciparum)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.680nMAssay Description:Inhibition of Plasmodium falciparum N-terminal thrombin cleavable His6-tagged ADA expressed in Escherichia coli BL21 assessed as reduction in formati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  14nMAssay Description:Inhibition of human erythrocytes ADA assessed as reduction in formation of inosine using adenosine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAdenosine deaminase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  1.29E+5nMAssay Description:Inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAdenosine deaminase(Bovine)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  1.00E+9nMAssay Description:Binding affinity (Ki) at calf intestinal adenosine deaminase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed