BDBM22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine

SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1

InChI Key InChIKey=ZUXABONWMNSFBN-UHFFFAOYSA-N

Data  408 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 413 hits for monomerid = 22869   

Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataIC50: 13nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataIC50: 100nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataIC50: 200nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataIC50: 7.10E+3nMAssay Description:The ability of Compound 102 to bind dopamine D2 receptors was measured in a cell-based assay. Dopamine D2 receptor cells were seeded in a half a blac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataIC50: 2.80E+3nMAssay Description:The ability of Compound 102 to bind the dopamine D2 receptor in a membrane preparation was examined. Medium was removed from dopamine D2 receptor cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  0.230nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  0.550nM ΔG°:  -11.7kcal/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Organon

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  0.980nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.30nM ΔG°:  -11.3kcal/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details Article
PubMed
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2012
Entry Details Article
PubMed
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.63nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.64nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2012
Entry Details Article
PubMed
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  2.07nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
University of North Carolina At Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Organon

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  2.59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  2.77nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
In Depth
Date in BDB:
2/24/2012
Entry Details
PubMed
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Guinea pig)
Uppsala University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Organon

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Acadia Pharmaceuticals

LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pharmacia & Upjohn

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Pharmacia & Upjohn

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
SynthÉLabo Recherche

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
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