BDBM50063753 CHEMBL12131::Closantel::N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide::N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-hydroxy-3,5-diiodo-benzamide::cid_42574

SMILES Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O

InChI Key InChIKey=JMPFSEBWVLAJKM-UHFFFAOYSA-N

Data  2 KI  17 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50063753   

TargetSporulation kinase A(Bacillus subtilis (strain 168))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of autophosphorylation of the two-component signal transduction system kinase was measured using the KinA/Spo0F regulatory system of Bacil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) incubated for 2 hrs in presence of staurosporine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetLong-chain-fatty-acid--AMP ligase FadD32(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Toulouse

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis FAAL32 using AMPC12 as substrate incubated for 50 mins and measured by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Ludwig-Maximilians University

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of SIRT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetChaperonin GroEL(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetThiosulfate sulfurtransferase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetThiosulfate sulfurtransferase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of refolded rhodanese (unknown origin) preincubated with Escherichia coli GroEL/GroES for 60 mins in absence of compound followed by compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetChitinase(Onchocerca volvulus)
The Skaggs Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Onchocerca volvulus L3 larvae chitinase using 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as a profluorescent substrate after 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetChitinase(Onchocerca volvulus)
The Skaggs Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetChitinase(Onchocerca volvulus)
The Skaggs Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataKi:  468nMAssay Description:Inhibition of Onchocerca volvulus L3 larvae chitinase using 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as a profluorescent substrate after 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetChitinase(Onchocerca volvulus)
The Skaggs Institute For Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataKi:  470nMAssay Description:Competitive inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed