BDBM50170654 (+-)-cis-4-(3-(4-tert-butylphenyl)-2-methylpropyl)-2,6-dimethylmorpholine::(2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine::CHEMBL372700::cis-2,6-dimethyl-4-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)morpholine::cis-4-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine::cis-4-(3-(p-tert-butylphenyl)-2-methylpropyl)-2,6-dimethylmorpholine::cis-fenpropimorph::fenpropimorph::fenpropimorph cis-form::fenpropimorphe

SMILES CC(CN1C[C@H](C)O[C@H](C)C1)Cc1ccc(cc1)C(C)(C)C

InChI Key InChIKey=RYAUSSKQMZRMAI-UHFFFAOYSA-N

Data  13 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50170654   

TargetDelta(14)-sterol reductase(Maize)
Institut De Botanique

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of Zea mays (maize) microsomal delta 8,14-steroid 14-reductase using delta 8,14-cholestadienol as substrate after 90 min by GC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetCycloeucalenol cycloisomerase(Maize)
Institut De Botanique

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Zea mays (maize) cycloeucalenol-obtusifolial isomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSterol-8,7-isomerase(Maize)
Institut De Botanique

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Zea mays (maize) delta8,delta7-sterol isomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Wisconsin School of Medicine and Public Health

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.00500nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in guinea pig brain microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Wisconsin School of Medicine and Public Health

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.00500nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Wisconsin School of Medicine and Public Health

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.00500nMAssay Description:Displacement of (+)-[3H]-pentazocine from sigma 1 receptor in guinea pig whole brain microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.0100nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Wisconsin School of Medicine and Public Health

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.0110nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in guinea pig liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.0110nMAssay Description:Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Wisconsin School of Medicine and Public Health

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.0110nMAssay Description:Displacement of (+)-[3H]-pentazocine from sigma 1 receptor in guinea pig liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetC-8 sterol isomerase ERG2(Baker's yeast)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.0500nMAssay Description:Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor expressed in Saccharomyces cerevisiae WA0More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Wisconsin School of Medicine and Public Health

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of (+)-[3H]-pentazocine from recombinant guinea pig His6-tagged sigma 1 receptor expressed in Saccharomyces cerevisiae WAO microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  17nMAssay Description:Displacement of (+)-[3H]-pentazocine from recombinant human sigma 1 receptor expressed in baculovirus infected Sf9 insect cell membranes after 90 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  30nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50170654((2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-...)
Affinity DataKi:  854nMAssay Description:Displacement of (+)-[3H]-ditolylguanidine from recombinant rat sigma 2 receptor expressed in rat PC12 cell membranes after 90 mins in presence of sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed