BDBM50049394 5,4'-Dihydroxy-6,7-dimethoxyflavone::5-Hydroxy-2-(4-hydroxy-phenyl)-6,7-dimethoxy-chromen-4-one::5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one::CHEMBL348436::Cirsimaritin::cid_188323::cirsimartin

SMILES COc1cc2oc(cc(=O)c2c(O)c1OC)-c1ccc(O)cc1

InChI Key InChIKey=ZIIAJIWLQUVGHB-UHFFFAOYSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50049394   

TargetNeutrophil cytosol factor 1 [S99G](Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataIC50: 5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2011
Entry Details
PCBioAssay
TargetAcetylcholinesterase(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
Target3-oxoacyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of FabGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Inifta (Unlp, Cct La Plata-Conicet)

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of rat lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of rat cortex homogenate AChE using acetylthiocholine iodide as substrate after 15 mins in presence of BuChE inhibitor iso-OMPA by Ellman'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2020
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Pig)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataIC50: 430nMAssay Description:Inhibition of porcine DPP4 after 30 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataKi:  1.20E+3nMAssay Description:Ability to displace [3H]N6-phenylisopropyladenosine binding from adenosine A1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataKi:  1.72E+3nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataKi:  3.00E+3nMAssay Description:Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataKi:  3.02E+3nMAssay Description:Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(cirsimartin | CHEMBL348436 | cid_188323 | 5-Hydrox...)
Affinity DataKi:  3.16E+3nMAssay Description:Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed