BDBM27213 4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole::CHEMBL14638::CHEMBL1795025::Ciproxifan

SMILES O=C(C1CC1)c1ccc(OCCCc2cnc[nH]2)cc1

InChI Key InChIKey=ACQBHJXEAYTHCY-UHFFFAOYSA-N

Data  51 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 27213   

TargetHistamine N-methyltransferase(Rat)
Freie Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition against histamine-metabolizing enzyme Histamine N-methyl-transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.427nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.490nMAssay Description:In vitro inhibitory activity against Histamine H3 receptor for K+ evoked depolarization-induced release of [3H]histamine from synaptosomes of rat cer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.490nMAssay Description:In vitro binding affinity against rat histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.490nMAssay Description:Histamine H3 receptor antagonist activity in an assay with K+ evoked depolarization-induced release of [3H]-histamine from rat synaptosomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.490nMAssay Description:Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral cortex for the release of [3H]histamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.510nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.630nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  0.654nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  1.74nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  1.74nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to rat Histamine H3 receptor in CHO-K1 cells using [125I]iodoproxyfan as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine receptor H3(Dog)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  5.75nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine receptor H3(Dog)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  5.75nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  42.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  46nMAssay Description:Inhibition of [125I]iodoproxyfan binding to human histamine H3 receptor of CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  46nMAssay Description:Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  46nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  62.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  63nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  63nM ΔG°:  -9.82kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  63nMAssay Description:Binding affinity to human H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  89.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  89.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  89.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  94nMAssay Description:Antagonist potency against human histamine H3 receptor expressed in CHO cells was determined by GTPgamma-S-assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  94nMAssay Description:Antagonist potency against human H3 receptor in GTPgamma-S-AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  302nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  612nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  612nMAssay Description:Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  1.86E+3nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  1.86E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  1.86E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi:  1.88E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi: >2.51E+3nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27213(CHEMBL1795025 | 4-[3-(4-cyclopropanecarbonylphenox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
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