BDBM50017657 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine::1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine::1-Benzhydryl-4-cinnamylpiperazin::1-Cinnamyl-4-(diphenylmethyl)piperazine::CHEMBL43064::cid_1547484::cinnarizine

SMILES c1ccc(cc1)/C=C/CN2CCN(CC2)C(c3ccccc3)c4ccccc4

InChI Key InChIKey=DERZBLKQOCDDDZ-UHFFFAOYSA-N

Data  1 KI  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50017657   

TargetEstrogen receptor(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2011
Entry Details
PCBioAssay
TargetEstrogen receptor beta(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 440nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 1.24E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in presence of 0.01% Triton X-100More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
The Centre For Addiction and Mental Health

Curated by PDSP Ki Database
LigandPNGBDBM50017657(1-Cinnamyl-4-(diphenylmethyl)piperazine | cid_1547...)
Affinity DataKi:  142nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2012
Entry Details Article
PubMed