BDBM50422828 CENICRIVIROC::CENICRIVIROC MESYLATE::TAK-652::TBR-652

SMILES CCCCOCCOc1ccc(cc1)-c1ccc2N(CC(C)C)CCCC(=Cc2c1)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC

InChI Key InChIKey=PNDKCRDVVKJPKG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50422828   

TargetC-C chemokine receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 5.90nMAssay Description:Displacement of [125I]MCP-1 from CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I]RANTES from CCR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 3.10nMAssay Description:Displacement of [125I]RANTES from CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 7(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [125I]MIP-3beta from CCR7 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 5.90nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50422828(TBR-652 | TAK-652 | CENICRIVIROC | CENICRIVIROC ME...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at CCR5 assessed as inhibition of CCL3 bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed