BDBM50382290 CARIPRAZINE HYDROCHLORIDE::RGH-188 HCL::US20240254109, Example Cariprazine

SMILES CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)c3cccc(c3Cl)Cl

InChI Key InChIKey=KPWSJANDNDDRMB-UHFFFAOYSA-N

Data  3 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50382290   

TargetD(1A) dopamine receptor(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to rat dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to human dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to human dopamine D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 16nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Shanghai Hansoh Biomedical

US Patent
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 0.890nMAssay Description:Dopamine D3 Receptor: Experimental buffer: 50 mM Tris-HCl pH 7.4, 10 mm MgCl2; washing liquor: 50 mM Tris-HCl pH 7.4, stored at 4° C.; 0.5% PEI solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Hansoh Biomedical

US Patent
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataIC50: 191nMAssay Description:5-HT2A Receptor: Experimental buffer: 50 mM Tris-HCl pH 7.4, 4 mM CaCl2); washing liquor: 50 mM Tris-HCl pH 7.4, stored at 4° C.; 0.5% PEI solution: ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity to human dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataKi:  0.810nMAssay Description:Binding affinity to human dopamine D2S receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50382290(RGH-188 HCL | CARIPRAZINE HYDROCHLORIDE | US202402...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to human dopamine D2L receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed