BDBM50203122 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine::5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)benzo-1,3-dioxolo(5,6-a)quinolizine::9,10-dimethoxy-2,3-(methylenedioxy)berbine::9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline::CHEMBL275097::Canadin::canadine::tetrahydroberberine::xanthopuccine

SMILES COc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC

InChI Key InChIKey=VZTUIEROBZXUFA-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50203122   

TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50203122(9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxo...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50203122(9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxo...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50203122(9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxo...)
Affinity DataIC50: 5.89E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50203122(9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxo...)
Affinity DataKi:  1.12E+3nMAssay Description:Displacement of [125I]-BE2254 from Wistar rat alpha1A adrenoceptor after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2018
Entry Details Article
PubMed