BDBM23866 MDL28170::Z-Val-Phe-CHO::benzyl N-[(1S)-2-methyl-1-[(1-oxo-3-phenylpropan-2-yl)carbamoyl]propyl]carbamate::calpain inhibitor III::med.21724, Compound 20
SMILES CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O
InChI Key InChIKey=NGBKFLTYGSREKK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 23866
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:Inhibition of µ-calpain was assayed in the reaction buffer (50 mM Tris-HCl, 50 mM NaCl, 1 mM EDTA, 1 mM EGTA and 5 mM β-mercaptoethanol, pH...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMpH: 7.5 T: 2°CAssay Description:Inhibition of m-calpain was assayed in the reaction buffer (50 mM Tris-HCl, 100 mM NaCl, 5 mM β-mercaptoethanol, and 1 mM EDTA, pH 7.5) with 50 ...More data for this Ligand-Target Pair
Affinity DataIC50: 95.8nMpH: 5.5 T: 2°CAssay Description:Inhibition of cathepsin B was assayed in reaction buffer (50 mM NaOAc-HCl, 2 mM dithiothreitol, 2 mM EDTA, pH 5.5) containing 20 µM substrate an...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMpH: 5.5 T: 2°CAssay Description:Inhibition of cathepsin L was assayed in reaction buffer (0.1M NaOAc-HCl, 1 mM EDTA, 0.1% β-mercaptoethanol, pH 5.5) containing 20 µM subst...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataKi: 10nM ΔG°: -10.8kcal/molepH: 7.4 T: 2°CAssay Description:Assays were initiated by addition of CaCl2, and the increase in fluorescence (ex @370 nm, em @440 nm) was monitored. MDL28170 and buffer with 2% DMSO...More data for this Ligand-Target Pair