BDBM50057513 (2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one::CHEMBL267144::benzolactam-V8

SMILES CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O

InChI Key InChIKey=OBEJTRHPRSRHSZ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50057513   

TargetProtein kinase C alpha type(Human)
Institute of Organic Chemistry

Curated by ChEMBL
LigandPNGBDBM50057513(benzolactam-V8 | (2S,5S)-5-Hydroxymethyl-2-isoprop...)
Affinity DataKi:  334nMAssay Description:Displacement of phorbol 12,13-dibutyrate (PDBU) from recombinant Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Institute of Organic Chemistry

Curated by ChEMBL
LigandPNGBDBM50057513(benzolactam-V8 | (2S,5S)-5-Hydroxymethyl-2-isoprop...)
Affinity DataKi:  334nMAssay Description:Displacement phorbol 12,13-dibutyrate(PDBU) binding from recombinant Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Institute of Organic Chemistry

Curated by ChEMBL
LigandPNGBDBM50057513(benzolactam-V8 | (2S,5S)-5-Hydroxymethyl-2-isoprop...)
Affinity DataKi:  334nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC alpha expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50057513(benzolactam-V8 | (2S,5S)-5-Hydroxymethyl-2-isoprop...)
Affinity DataKi:  410nMAssay Description:Displacement of [3H]PDBu from PKCdelta C1B domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50057513(benzolactam-V8 | (2S,5S)-5-Hydroxymethyl-2-isoprop...)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]PDBu from recombinant Protein kinase C deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50057513(benzolactam-V8 | (2S,5S)-5-Hydroxymethyl-2-isoprop...)
Affinity DataKi:  3.10E+3nMAssay Description:Displacement of [3H]PDBu from PKCgamma C1A domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed