BDBM50089916 BENZONIDAZOLE::Benznidazole::CHEMBL110::N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide::N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide (Benznidazole)::N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide::N-benzyl-2-(2-nitro-1H-imidazol-5-yl)acetamide::N-benzyl-2-(2-nitro-1Himidazol-1-yl)acetamide::N-benzyl-2-nitro-1-imidazoleacetamide::benznidazol

SMILES [O-][N+](=O)c1nccn1CC(=O)NCc1ccccc1

InChI Key InChIKey=CULUWZNBISUWAS-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50089916   

TargetGlyceraldehyde-3-phosphate dehydrogenase(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibition of rabbit muscle GAPDH.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal CYP2C9 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG incubated for 2 hrs by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal CYP1A2 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 7.78E+4nMAssay Description:Inhibition of human microsomal CYP2D6 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 9.82E+4nMAssay Description:Inhibition of human microsomal CYP3A4 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full-length human aurora B kinase expressed in baculovirus system using MBP as substrate incubated for 45 mins by ADP-glo k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50089916(benznidazol | CHEMBL110 | Benznidazole | N-benzyl-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal CYP2C19 expressed in baculovirus infected BTI-TN-5B1-4 cells incubated for 30 mins by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed