BDBM50241945 Atractylenolide III::CHEMBL486961

SMILES CC1=C2C[C@H]3C(=C)CCC[C@]3(C)C[C@]2(O)OC1=O

InChI Key InChIKey=FBMORZZOJSDNRQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50241945   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Heinrich-Heine-UniversitäT DüSseldorf

Curated by ChEMBL
LigandPNGBDBM50241945(Atractylenolide III | CHEMBL486961)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Heinrich-Heine-UniversitäT DüSseldorf

Curated by ChEMBL
LigandPNGBDBM50241945(Atractylenolide III | CHEMBL486961)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50241945(Atractylenolide III | CHEMBL486961)
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of human SOAT1 mediated [14C]Cholesterol ester synthesis in CHO cells after 6 hrs in presence of [14C]Oleic acid by TLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetSterol O-acyltransferase 2(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50241945(Atractylenolide III | CHEMBL486961)
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of human SOAT2-mediated [14C]Cholesterol ester synthesis in CHO cells after 6 hrs in presence of [14C]Oleic acid by TLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50241945(Atractylenolide III | CHEMBL486961)
Affinity DataIC50: 5.51E+4nMAssay Description:Inhibition of human SOAT1-mediated [14C]Cholesterol ester biosynthesis in CHO microsomal fraction after 5 mins in presence of [1-14C]oleoyl-CoA by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetSterol O-acyltransferase 2(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50241945(Atractylenolide III | CHEMBL486961)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of human SOAT2-mediated [14C]Cholesterol ester biosynthesis in CHO microsomal fraction after 5 mins in presence of [1-14C]oleoyl-CoA by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed