BDBM50241243 3,4',5,7-Tetrahydroxyflavone-3-glucoside::3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::4H-1-Benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-::5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl beta-D-glucopyranoside::Astragalin::CHEMBL233930::cid_5282102::kaempferol 3-O-glucoside

SMILES OC[C@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key InChIKey=VLAZVXDNDNYUKJ-UHFFFAOYSA-N

Data  5 KI  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50241243   

TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetBifunctional epoxide hydrolase 2(Human)
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetPancreatic triacylglycerol lipase(Pig)
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataIC50: 6.05E+4nMAssay Description:Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSialidase(Clostridium perfringens)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataIC50: 2.94E+4nMAssay Description:Inhibition of Clostridium perfringens neuraminidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Institute of Oriental Medicine

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataIC50: 5.09E+3nMAssay Description:Inhibition of rat lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataEC50:  7.28E+4nMAssay Description:Inhibition of Influenza A virus A/PR/8/34 (H1N1) neuraminidase activity measured in infected MDCK cells using MUNANA as substrate assessed as fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rat)
Ehime University

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataIC50: 4.01E+5nMAssay Description:Inhibition of rat lung ACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of Zika virus NS2B (1421 to 1469 residues) - NS3 (1503 to 1688 residues) expressed in Escherichia coli BL21(DE3) cells using Dabcyl-KTSAVL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataKi:  4.90nM ΔG°:  -11.3kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataKi:  168nM ΔG°:  -9.24kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataKi:  424nM ΔG°:  -8.69kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataKi:  5.59E+3nM ΔG°:  -7.16kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Aristotle University of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50241243(3,4',5,7-Tetrahydroxyflavone-3-glucoside | CHEMBL2...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed