BDBM50321885 (E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimethylimidazolidin-4-one::CHEMBL404232::aplysinopsin

SMILES CN1C(=N)N(C)\C(=C\c2c[nH]c3ccccc23)C1=O

InChI Key InChIKey=AZGOVLGMSGAOMP-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50321885   

TargetAmine oxidase [flavin-containing] B(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50321885((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50321885((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50321885((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...)
Affinity DataKi:  598nMAssay Description:Displacement of [3H]methylspiperone from human cloned 5HT2A receptor expressed in HEK293 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50321885((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...)
Affinity DataKi:  3.03E+3nMAssay Description:Displacement of [3H]GR65630 from human recombinant 5HT3 receptor expressed in HEKT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of North Texas Health Science Center

Curated by ChEMBL
LigandPNGBDBM50321885((E)-5-((1H-Indol-3yl)methylene)-2-imino-1,3-dimeth...)
Affinity DataKi:  1.45E+4nMAssay Description:Displacement of [3H]mesulergine from human cloned 5HT2C receptor expressed in HEK293 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed