BDBM85515 Ampyrone::CAS_83-07-8::EN300-17058::NSC_2151::US11643395, Compound 9

SMILES Cc1c(N)c(=O)n(-c2ccccc2)n1C

InChI Key InChIKey=RLFWWDJHLFCNIJ-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 85515   

TargetProstaglandin G/H synthase 1(Sheep)
Minia University

Curated by ChEMBL
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver estera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Minia University

Curated by ChEMBL
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver est...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Philipps-Universit£T

Curated by ChEMBL
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of COX-2 in C57BL/6 mouse brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Philipps-Universit£T

Curated by ChEMBL
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of COX-1 in C57BL/6 mouse brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Individual

US Patent
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataIC50: 6.97E+4nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataIC50: 3.41E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Minia University

Curated by ChEMBL
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Minia University

Curated by ChEMBL
LigandPNGBDBM85515(CAS_83-07-8 | NSC_2151 | Ampyrone | US11643395, Co...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed