BDBM50052593 3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine::3-Ethynyl-5-((S)-1-methyl-pyrrolidin-2-yl)-pyridine::Altinicline::CHEMBL111659::US10667515, Compound (S)-SIB 1508Y

SMILES CN1CCC[C@H]1c1cncc(c1)C#C

InChI Key InChIKey=NUPUDYKEEJNZRG-UHFFFAOYSA-N

Data  1 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50052593   

LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  1.80E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta2 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  1.80E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta2 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataIC50: 8.90E+3nMAssay Description:Muscarinic acetylcholine receptor binding (rat cortical membranes) was determined by displacement of [3H]quinuclidinyl benzylate [3H]QNB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  5.00E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  5.00E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  2.30E+4nMAssay Description:The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  2.30E+4nMAssay Description:The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  3.20E+3nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  3.20E+3nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  320nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetResistance to inhibitors of cholinesterase protein 3(Pig roundworm)
Iowa State University Research Foundation

US Patent
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  370nMAssay Description:Nematode eggs are isolated from fresh feces by centrifugation and flotation. The eggs are washed and inspected to confirm embryonation has not starte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent