BDBM50113332 3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one::3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-thioxo-2,3-dihydro-1H-quinazolin-4-one::CHEMBL62919::altanserin

SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1

InChI Key InChIKey=SMYALUSCZJXWHG-UHFFFAOYSA-N

Data  15 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50113332   

Target5-hydroxytryptamine receptor 2A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at recombinant human 5-HT2A expressed in human U2OS cells by pathhunter beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]-Ketanserin from rat frontal cortex 5-HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]altanserine from rat cortical membrane 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  0.130nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor in humansMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  0.720nMAssay Description:Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyserMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  0.740nMAssay Description:Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-WB4101 from rat forebrain alpha 1 adrenergic receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  40nMAssay Description:Binding affinity to 5HT2C receptor by competitive binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  62nMAssay Description:Binding affinity to dopamine D2 receptor by competitive binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]-halopridol from rat striatum D2 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  71nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Pharmaceutica

Curated by PDSP Ki Database
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz

Curated by ChEMBL
LigandPNGBDBM50113332(CHEMBL62919 | altanserin | 3-(2-(4-(4-fluorobenzoy...)
Affinity DataKi:  1.57E+3nMAssay Description:Binding affinity to 5-HT1A receptor by competitive binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed