BDBM50089194 (R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide::(R)-N4-hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide::ACTINONIN::CHEMBL308333::N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-(R)-pentyl-succinamide::N*4*-Hydroxy-N*1*-[1-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide

SMILES CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO

InChI Key InChIKey=XJLATMLVMSFZBN-UHFFFAOYSA-N

Data  10 KI  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50089194   

TargetPeptide deformylase, mitochondrial(Human)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human mitochondrial PDFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPeptide deformylase, mitochondrial(Human)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human PDF expressed in Escherichia coli BL21 pLysS using formyl-Met-Ala-His-Ala peptide as substrate measured after 1 hr by fluorescami...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPeptide deformylase, mitochondrial(Human)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human PDF using N-formylated peptide as substrate in presence of NAD+ by formate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 2.59E+5nMAssay Description:Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 830nMAssay Description:Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 400nMAssay Description:Competitive inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPeptide deformylase(Staphylococcus aureus)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptide deformylase(Staphylococcus aureus subsp. aureus Mu50)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Staphylococcus aureus peptide deformylase using N-formylmethionine-alanine-serine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeptide deformylase, mitochondrial(Human)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibitory concentration required against peptide deformylase (PDF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptide deformylase(Escherichia coli)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDF1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetPeptide deformylase 1A, chloroplastic/mitochondrial(Mouse-ear cress)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 27nMAssay Description:Inhibition of Arabidopsis thaliana mitochondrial PDF1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetPeptide deformylase(Escherichia coli)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetPeptide deformylase(Escherichia coli)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Escherichia coli peptide deformylase using fMAHA as substrate after 1 hr by FLUO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
British Biotech Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
British Biotech Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 6.70E+3nMAssay Description:The compound was evaluated in vitro for the inhibition of Neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
British Biotech Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptide deformylase, mitochondrial(Human)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 10nMAssay Description:Antibacterial activity against Escherichia coli Peptide deformylase. NiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
British Biotech Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
British Biotech Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was tested for its inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeptide deformylase, mitochondrial(Human)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human peptide deformylase after 1 hr by fluorescence polarization based competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetPeptide deformylase, mitochondrial(Human)
Centre National De La Recherche Scientifique

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards Peptide deformylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  170nMAssay Description:Competitive inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  190nMAssay Description:Inhibition of human Matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetInterstitial collagenase(Human)
British Biotech Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  300nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  330nMAssay Description:Inhibition of human Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
British Biotech Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetMeprin A subunit beta(Human)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
TargetMeprin A subunit beta(Human)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of recombinant human meprin beta expressed in baculovirus infected insect cells using N-benzoyl-L-tyrosyl-p-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  3.00E+5nMAssay Description:Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-2 degradation after 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50089194(CHEMBL308333 | N*4*-Hydroxy-N*1*-[1-(2-hydroxymeth...)
Affinity DataKi:  3.90E+5nMAssay Description:Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-1 degradation after 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed