BDBM50008936 (S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::9-aminocamptothecan::CHEMBL274070::cid_72402

SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc(N)c4cc3Cn1c2=O

InChI Key InChIKey=FUXVKZWTXQUGMW-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50008936   

TargetHeat shock factor protein 1(Mouse)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50008936(cid_72402 | 9-aminocamptothecan | CHEMBL274070 | 1...)
Affinity DataEC50: >2.60E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2011
Entry Details
PCBioAssay
TargetDNA topoisomerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50008936(cid_72402 | 9-aminocamptothecan | CHEMBL274070 | 1...)
Affinity DataIC50: 4.20E+3nMAssay Description:Compound was tested in vitro for inhibition of topoisomerase I.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetDNA topoisomerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50008936(cid_72402 | 9-aminocamptothecan | CHEMBL274070 | 1...)
Affinity DataIC50: 1.80E+3nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetDNA topoisomerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50008936(cid_72402 | 9-aminocamptothecan | CHEMBL274070 | 1...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in intact human HL-60 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2012
Entry Details Article
PubMed