BDBM50275147 6-Gingerol::BDBM50317427::CHEMBL446043::Gingerol::[6]-gingerol

SMILES CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1

InChI Key InChIKey=NLDDIKRKFXEWBK-UHFFFAOYSA-N

Data  1 KI  17 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50275147   

TargetCytochrome P450 2C9(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in baculosomes using Vivid OOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetHTH-type quorum-sensing regulator RhlR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Korea University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 9.45E+5nMAssay Description:Antagonist activity at Pseudomonas aeruginosa RhlR expressed in Escherichia coli DH5alpha incubated for 1.5 hrs by luminescence reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 2.79E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 7 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 4.08E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 7.34E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 3.07E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid DBOMF substrate green measured every 30 sec for 30 mins by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 3.74E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 4.29E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataEC50:  1.04E+4nMAssay Description:Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins pri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Department of Chemistry and Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50275147([6]-gingerol | Gingerol | BDBM50317427 | CHEMBL446...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed