BDBM7398 (2 Z)-6 -Bromoindirubin::6 -bromoindirubin::6-bromo-2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-dihydro-1H-indol-3-one::indirubin deriv. 12a

SMILES Brc1ccc2C(=O)\C(Nc2c1)=C1\C(=O)Nc2ccccc12

InChI Key InChIKey=DELRXTMEZKHWMU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7398   

TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
University of Athens

LigandPNGBDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
Affinity DataIC50: 2.20E+4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
University of Athens

LigandPNGBDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Central University

Curated by ChEMBL
LigandPNGBDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
Affinity DataIC50: 4nMAssay Description:Competitive inhibition of glycogen synthase kinase-3 beta (unknown origin) using GS-1 as substrate after 30 mins by scintillation counting analysis i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed