BDBM50055710 4-HYDROXY-2H-CHROMEN-2-ONE::4-Hydroxy-chromen-2-one::4-hydroxycoumarin::CHEMBL301141

SMILES c1ccc2c(c1)C(=CC(=O)O2)O

InChI Key InChIKey=VXIXUWQIVKSKSA-UHFFFAOYSA-N

Data  4 KI  5 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50055710   

TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataIC50: 1.00E+5nMAssay Description:Integration of DNA by HIV -1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against 3'-processing of DNA by HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of xanthine oxidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition human recombinant aldose reductase 1 by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetSorbitol dehydrogenase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition sorbitol dehydrogenase by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataKi:  410nMAssay Description:Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataKi:  9.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50055710(4-Hydroxy-chromen-2-one | 4-HYDROXY-2H-CHROMEN-2-O...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2017
Entry Details Article
PubMed