BDBM50240701 2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-benzo[f]azulene::4-Desmethylolanzapine::CHEMBL1125::desmethylolanzapine::olanzapine, N-desmethyl

SMILES Cc1cc2c(Nc3ccccc3N=C2N2CCNCC2)s1

InChI Key InChIKey=FHPIXVHJEIZKJW-UHFFFAOYSA-N

Data  10 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50240701   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity of compound against neuronal Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  22nMAssay Description:In vitro binding affinity of compound against histamine H1 neuronal receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSerotonin 2 (5-HT2) receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  23nMAssay Description:In vitro binding affinity of compound against neuronal 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetD(2) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  80nMAssay Description:In vitro binding affinity of compound against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetD(1A) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  203nMAssay Description:In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  333nMAssay Description:In vitro binding affinity of compound against muscarinic neuronal receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi:  1.00E+3nMAssay Description:In vitro binding affinity of compound against neuronal alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50240701(CHEMBL1125 | 2-Methyl-10-piperazin-1-yl-4H-3-thia-...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity of compound against neuronal Beta adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article