BDBM50053595 4-Chloro-Phenyl biguanide::4-Chlorophenylbiguanide::CHEMBL840::N-(4-chlorophenyl)imidodicarbonimidic diamide

SMILES NC(=N)N=C(N)Nc1ccc(Cl)cc1

InChI Key InChIKey=HTYFFCPFVMJTKM-UHFFFAOYSA-N

Data  1 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50053595   

TargetIntegrin alpha-V/beta-3(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50053595(4-Chlorophenylbiguanide | N-(4-chlorophenyl)imidod...)
Affinity DataIC50: 1.49E+5nMAssay Description:Inhibition of integrin alphavbeta3 mediated cell adhesion of human M21 cells to vitronectinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50053595(4-Chlorophenylbiguanide | N-(4-chlorophenyl)imidod...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50053595(4-Chlorophenylbiguanide | N-(4-chlorophenyl)imidod...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetTrace amine-associated receptor 5(Mouse)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50053595(4-Chlorophenylbiguanide | N-(4-chlorophenyl)imidod...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50053595(4-Chlorophenylbiguanide | N-(4-chlorophenyl)imidod...)
Affinity DataKi:  200nMAssay Description:Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed