BDBM50329578 (-)-9-Bromocytisine::(1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one::3-bromocytisine::CHEMBL365956

SMILES Brc1ccc2[C@H]3CNC[C@H](C3)Cn2c1=O

InChI Key InChIKey=DWDCLEHDNICBMI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50329578   

LigandPNGBDBM50329578((-)-9-Bromocytisine | (1R,5S)-9-Bromo-1,2,3,4,5,6-...)
Affinity DataIC50: 15.6nMAssay Description:Displacement of [3H]epibatidine from alpha3 nAChR in human IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Instituto De Investigaciones Biol£Gicas Clemente Estable

Curated by ChEMBL
LigandPNGBDBM50329578((-)-9-Bromocytisine | (1R,5S)-9-Bromo-1,2,3,4,5,6-...)
Affinity DataIC50: 0.309nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Instituto De Investigaciones Biol£Gicas Clemente Estable

Curated by ChEMBL
LigandPNGBDBM50329578((-)-9-Bromocytisine | (1R,5S)-9-Bromo-1,2,3,4,5,6-...)
Affinity DataKi:  0.116nMAssay Description:Displacement of [3H]cytisine from rat alpha4beta2 nAChR in rat brain cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Ensicaen-Université

Curated by ChEMBL
LigandPNGBDBM50329578((-)-9-Bromocytisine | (1R,5S)-9-Bromo-1,2,3,4,5,6-...)
Affinity DataKi:  401nMAssay Description:Displacement of [125I]alpha-Bungarotoxin from alpha7 nAchR in rat brain cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed