BDBM50064482 2-demethylthiocolchicine::CHEMBL277239::N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide::N-(2-Hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(SC)ccc3-c2c(OC)c1O

InChI Key InChIKey=OMQLBXIHBJAOIO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50064482   

TargetTubulin beta-1 chain(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50064482(N-(2-Hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory concentration against tubulin assemblyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50064482(N-(2-Hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo...)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed