BDBM50028197 2-(difluoromethyl)ornithine::CHEMBL830::EFLORNITHINE

SMILES C(CC(C(F)F)(C(=O)O)N)CN

InChI Key InChIKey=VLCYCQAOQCDTCN-UHFFFAOYSA-N

Data  1 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50028197   

LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human mitochondrial HSP60/HSP10-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Escherichia coli GroEL/GroES-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human mitochondrial HSP60/HSP10 expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Escherichia coli GroEL/GroES expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMitochondrial 2-oxodicarboxylate carrier(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataIC50: 2.52E+5nMAssay Description:Inhibition of ODC (unknown origin) expressed in Escherichia coli after 30 mins in presence of [1-14C] L-ornithine by liquid scintillation counter ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details
PubMed
TargetOrnithine decarboxylase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50028197(2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNIT...)
Affinity DataKi:  3.90E+4nMAssay Description:The apparent dissociation constant for irreversible inhibition of rat liver ornithine decarboxylase (ODC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed