BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

45 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Acyclic tethers mimicking subunits of polysaccharide ligands: selectin antagonists.EBI
Institut De Recherches Cliniques De Montr£Al (Ircm)
A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors.EBI
Johannes Gutenberg University
Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists?EBI
University of Basel
Rational design of novel, potent small molecule pan-selectin antagonists.EBI
Revotar Biopharmaceuticals
Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors.EBI
Griffith University (Gold Coast Campus)
Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.EBI
Ontogen
Study on selectin blocker. 8. Lead discovery of a non-sugar antagonist using a 3D-pharmacophore model.EBI
Nippon Organon K.K.
Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269).EBI
Texas Biotechnology
Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides.EBI
Kanebo
Studies on selectin blockers. 6. Discovery of homologous fucose sugar unit necessary for E-selectin binding.EBI
Kanebo
Studies on selection blockers. 5. Design, synthesis, and biological profile of sialyl Lewis x mimetics based on modified serine-glutamic acid dipeptides.EBI
Kanebo
Studies on selectin blocker. 1. Structure-activity relationships of sialyl Lewis X analogs.EBI
Institute of Cancer Research
Studies on selectin blockers. 2. Novel selectin blocker as potential therapeutics for inflammatory disorders.EBI
New Drug Research Laboratory
Rational design and synthesis of small molecule, non-oligosaccharide selectin inhibitors: (alpha-D-mannopyranosyloxy)biphenyl-substituted carboxylic acids.EBI
Texas Biotechnology
Design and synthesis of a new sialyl Lewis X mimetic: how selective are the selectin receptors?EBI
University of Montreal
Synthesis of sialyl Lewis(x) mimics. Modifications of the 6-position of galactose.EBI
Novartis Pharma
Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors.EBI
Wyeth Research
Synthesis of novel sialylmimetics as biological probes.EBI
Monash University (Parkville Campus)
A solid-phase synthesis for beta-turn mimetics of sialyl Lewis X.EBI
Nippon Organon K.K.
Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.EBI
University of Montreal
Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction.EBI
Scripps Research Institute
 
Synthesis and inhibitory effects of bivalent sialyl lewis X analogs at preventing cell adhesionEBI
TBA
 
Synthesis and biological activity of conformationally constrained sialyl Lewis X analogues with reduced carbohydrate characterEBI
TBA
 
Liposome-like fucopeptides as sialyl lewis X mimeticsEBI
TBA
 
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimicEBI
TBA
Synthesis of fluorinated C-mannopeptides as sialyl Lewisx mimics for E- and P-selectin inhibition.EBI
University of Rouen Normandy
 
Chemical and enzymatic synthesis of high-affinity selectin ligandsEBI
TBA
 
Glycomimetic selectin inhibitors: (α-D-mannopyranosyloxy)methylbiphenylsEBI
TBA
 
Synthesis and biological activity of novel sialyl-lewisX conjugatesEBI
TBA
 
Stereoselective synthesis of lewis-associated trisaccharides as E-selectin inhibitorsEBI
TBA
Sialyl Lewis(x) analogs based on a quinic acid scaffold as the fucose mimic.EBI
National Chemical Engineering Institute In Paris
Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.EBI
Abbott Laboratories
Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.EBI
Abbott Laboratories
Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition.EBI
Novartis Pharma
Synthesis and biological evaluation of a potent E-selectin antagonist.EBI
Novartis Pharma
Aryl C-glycosides: physiologically stable glycomimetics of sialyl Lewis X.EBI
Sankyo
Sialyl Lewis X-polysaccharide conjugates: targeting inflammatory lesions.EBI
Drug Delivery System Institute
Selectin-ligand interactions revealed by molecular dynamics simulation in solution.EBI
Kanebo
Ligand interactions with E-selectin. Identification of a new binding site for recognition of N-acyl aromatic glucosamine substituents of sialyl Lewis X.EBI
Cytel
3-Alkoxybenzo[b]thiophene-2-carboxamides as inhibitors of neutrophil-endothelial cell adhesion.EBI
Warner-Lambert
Structure--activity relationships of sialyl Lewis x-containing oligosaccharides. 1. Effect of modifications of the fucose moiety.EBI
Cytel
Bicyclic pyrazolyl amines as CDK2 inhibitorsBDB
Incyte
Amino pyrimidine derivativesBDB
Novartis