21 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.
University of Tsukuba
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.
University of Tsukuba
Design and synthesis of quinolinopropellane derivatives with selectived opioid receptor agonism.
University of Tsukuba
Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton.
University of Tsukuba
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
University of Tsukuba
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives.
University of Tsukuba
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.
University of Tsukuba
Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.
University of Tsukuba
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
University of Tsukuba
Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.
University of Tsukuba
Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance.
University of Tsukuba
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.
University of Tsukuba
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.
University of Tsukuba
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.
University of Tsukuba
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.
University of Tsukuba
Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.
University of Tsukuba
Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloidβ aggregation.
University of Tsukuba
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.
University of Tsukuba
Antitrichomonal activity ofδ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.
University of Tsukuba
Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
University of Texas