25 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Indolylpiperidine derivatives as potent and selectivea1B adrenoceptor antagonists.
Toray Industries
Identification of alpha-substituted acylamines as novel, potent, and orally active mGluR5 negative allosteric modulators.
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The discovery of potent glycine transporter type-2 inhibitors: design and synthesis of phenoxymethylbenzamide derivatives.
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Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.
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Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.
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Discovery of potent transient receptor potential vanilloid 1 antagonists: design and synthesis of phenoxyacetamide derivatives.
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Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.
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Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors.
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Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists.
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Design and synthesis of novel p38a MAP kinase inhibitors: discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety.
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Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.
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Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.
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Efficient synthesis of a novel m-phenylene derivative as a selective EP4 agonist inducing follicular growth and maturation in the ovary.
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(3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
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Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.
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Discovery of orally bioavailable inhibitors of MALT1 with in vivo activity for psoriasis.
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Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives.
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Structure-activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease.
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Discovery of highly selectiveκ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives.
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Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Center For Free-Electron Laser Science