24 articles for thisTarget
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Structure-based design of novel, urea-containing FKBP12 inhibitors.
Agouron Pharmaceuticals
Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.
Agouron Pharmaceuticals
Characterization of mono- and diaminopyrimidine derivatives as novel, nonpeptide gonadotropin releasing hormone (GnRH) receptor antagonists.
Agouron Pharmaceuticals
The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists.
Agouron Pharmaceuticals
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.
Agouron Pharmaceuticals
Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation.
Agouron Pharmaceuticals
Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists.
Agouron Pharmaceuticals
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
Agouron Pharmaceuticals
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.
Agouron Pharmaceuticals
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.
Agouron Pharmaceuticals
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.
Agouron Pharmaceuticals
Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.
Agouron Pharmaceuticals
Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.
Agouron Pharmaceuticals
Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.
Agouron Pharmaceuticals
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.
Agouron Pharmaceuticals
Calculation of relative differences in the binding free energies of HIV1 protease inhibitors: a thermodynamic cycle perturbation approach.
Agouron Pharmaceuticals
Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.
Agouron Pharmaceuticals
Design of enzyme inhibitors using iterative protein crystallographic analysis.
Agouron Pharmaceuticals
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.
Agouron Pharmaceuticals
Kinase modulating compounds, compositions containing the same and use thereof
Centaurus Biopharma
Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
SRMLSC