Binding Database

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor.

Central Pharmaceutical Research Institute

Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).

University of Southampton

Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer.

Ocean University of China

Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.

Emory University

Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors

Array Biopharma

Compounds as diacylglycerol acyltransferase inhibitors

Glaxosmithkline

Methods for treating depressive symptoms

Alkermes Pharma Ireland

Evaluating scoring functions for docking and designing beta-secretase inhibitors.

Merck Research Laboratories

Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites.

Merck Research Laboratories

Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification.

Vernalis (R&D)