The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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50 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.EBI
Purdue University
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.EBI
Korea Research Institute of Bioscience and Biotechnology
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.EBI
University of Alberta
Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China.EBI
Qufu Normal University
Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.EBI
Univ. Lille
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective.EBI
University of Siena
Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.EBI
Peking University
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.EBI
Purdue University
Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors.EBI
Development Center For Biotechnology
Two Binding Sites of SARS-CoV-2 Macrodomain 3 Probed by Oxaprozin and Meclomen.EBI
University of Science and Technology of China
THERAPEUTIC ALKALOID COMPOUNDSBDB
Sensorium Therapeutics
Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activityBDB
Shionogi
7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma- secretase modulators for the treatment of alzheimer's diseaseBDB
Hoffmann-La Roche
Compounds having PDE9A inhibitory activity, and pharmaceutical uses thereofBDB
Korea Research Institute of Chemical Technology
HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCERBDB
Artios Pharma
SALT TYPES OF TRICYCLIC TETRAHYDRO ISOQUINOLINE DERIVATIVEBDB
Jiangsu Hengrui Pharmaceuticals
Substituted pyrazolo[1,5-a]pyridine compound, composition containing the same and use thereofBDB
Shenzhen Targetrx
KRAS G12D INHIBITOR AND USE THEREOFBDB
Shanghai De Novo Pharmatech
3-[(1H-PYRAZOL-R-YL)OXY]PYRAZIN-2-AMINE COMPOUNDS AS HPK1 INHIBITOR AND USE THEREOFBDB
Beigene
METHODS OF TREATING ACUTE RESPIRATORY DISTRESS SYNDROME WITH ACTIVATORS OF TIE-2BDB
Aerpio Pharmaceuticals
Pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2BDB
Hoffmann-La Roche
3-AMINO PIPERIDYL SODIUM CHANNEL INHIBITORSBDB
Genentech
SULFONE- AND SULFOXIMINE-BASED SELECTIVE PARP1 INHIBITORSBDB
Enliven
BENZOTHIAZOLE AND QUINOLINE DERIVATIVES FOR USE IN TREATING KAWASAKI DISEASEBDB
Shanghai Yao Yuan Biotechnology Co.
GALACTOPYRANOSYL-CYCLOHEXYL DERIVATIVES AS E-SELECTIN ANTAGONISTSBDB
Glycomimetics
Substituted cyclopenta[c]pyrroles as ABHD6 antagonistsBDB
Ono Pharmaceutical Co.
INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASEBDB
Cornell University
PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORSBDB
Actelion Pharmaceuticals
Diacylglyercol kinase modulating compoundsBDB
Gilead Sciences
HETEROCYCLIC COMPOUND AS DIACYLGLYCEROL KINASE INHIBITOR AND USE THEREOFBDB
Lg Chem
SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORSBDB
Hoffmann-La Roche
N-(2-(3-CYANO-2-AZABICYCLO[3.1.0]HEXAN-2-YL)-2-OXOETHYL)QUINOLINE-4-CARBOXAMIDESBDB
Astrazeneca
PYRAZOLEAMIDE DERIVATIVESBDB
Hoffmann-La Roche
Therapeutic compounds and methods of useBDB
Genentech
Compound having PD-L1 inhibitory activity, preparation method therefor and use thereofBDB
Shanghai Ennovabio Pharmaceuticals
Pyrazolopyrimidine compounds as adenosine receptor antagonistsBDB
Exscientia
CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOFBDB
Jiangsu Tasly Diyi Pharmaceutical
Inhibitors of receptor interacting protein kinase I for the treatment of diseaseBDB
University Of Texas
Compounds and methods for the enhanced degradation of targeted proteinsBDB
Arvinas Operations
Azaspirocycles as monoacylglycerol lipase modulatorsBDB
Janssen Pharmaceutica
KRAS mutant protein inhibitorsBDB
Jacobio Pharmaceuticals
Quaternary lactam compound and pharmaceutical use thereofBDB
Shanghai Meiyue Biotech Development
4H-pyrrolo[3,2-c]pyridin-4-one derivativesBDB
Bayer Aktiengesellschaft
Thiazolidinone compounds and use thereofBDB
National Health Research Institute
Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancerBDB
University of Pittsburgh
2,4-disubstituted pyrimidines as CDK inhibitorsBDB
Shanghai Xunhe Pharmaceutical Technology
Inhibitors of pyruvate kinase and methods of treating diseaseBDB
Beth Israel Deaconess Medical Center
Structure-based design and synthesis of substituted 2-butanols as nonpeptidic inhibitors of HIV protease: secondary amide series.BDB
Agouron Pharmaceuticals