The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

16 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.EBI
University of Catania
Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position.EBI
Queen'S University
Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties.EBI
University of Catania
Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.EBI
Queen'S University
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.EBI
Queen'S University
X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.EBI
Queen'S University
Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.EBI
Queen'S University
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent EBI
University of Catania
Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application.EBI
University of Catania
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.EBI
University of Catania
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines.EBI
University of Catania
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.EBI
University of Catania
Monoacylglycerol lipase modulatorsBDB
Janssen Pharmaceutica
Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disordersBDB
The University of Mississippi
Tricyclic pyrido-carboxamide derivatives as rock inhibitorsBDB
Bristol-Myers Squibb
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.BDB
Consiglio Nazionale Delle Ricerche