37 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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The synthesis and evaluation of temperature sensitive tubulin toxins.
University of Virginia
Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles.
University of Virginia
Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability.
University of Virginia
DNA polymerase beta lyase inhibitors from Maytenus putterlickoides.
University of Virginia
N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.
University of Virginia
6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency.
University of Virginia
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.
University of Virginia
Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.
University of Virginia
Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.
University of Virginia
Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.
University of Virginia
Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts.
University of Virginia
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.
University of Virginia
Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX).
University of Virginia
Cellular characterization of a novel focal adhesion kinase inhibitor.
University of Virginia
(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA.
University of Virginia
Biscoumarin derivatives from Edgeworthia gardneri that inhibit the lyase activity of DNA polymerase beta.
University of Virginia
A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta.
University of Virginia
Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata.
University of Virginia
bis-5-Alkylresorcinols from Panopsis rubescens that inhibit DNA polymerase beta.
University of Virginia
Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.
University of Virginia
Homo-cysteinyl peptide inhibitors of the L1 metallo-beta-lactamase, and SAR as determined by combinatorial library synthesis.
University of Virginia
Small-Molecule Inhibitors of the MLL1 CXXC Domain, an Epigenetic Reader of DNA Methylation.
University of Virginia
A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist.
University of Virginia
Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist.
University of Virginia
Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics.
University of Virginia
2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors.
University of Virginia
(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.
University of Virginia
Synthesis and structure-activity profiles of A-homoestranes, the estratropones.
University of Virginia
Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist.
University of Virginia
Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.
University of Virginia
SAR studies for a new class of antibacterial NAD biosynthesis inhibitors.
University of Alabama At Birmingham
Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.
University of Zurich